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Article

BCL2 expression in chronic lymphocytic leukemia: lack of association with the BCL2 938A>C promoter single nucleotide polymorphism.

Blood - 15 Jan 2008

Majid Aneela, Tsoulakis Olga, Walewska Renata, Gesk Stefan, Siebert Reiner, Kennedy D Ben J, Dyer Martin J S

Abstract excerpt

High-level BCL2 expression is seen in most patients with chronic lymphocytic leukemia (CLL) in the absence of BCL2 chromosomal translocation. A single nucleotide polymorphism (SNP; -938C>A) within an inhibitory region of the BCL2 promoter has been reported to regulate BCL2 protein expression and to be associated with adverse prognostic features in CLL. We screened 276 patients with CLL for this SNP and 100...

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Share to Drug Resistance, Neoplasm
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Proto-Oncogene Proteins c-bcl-2

Share to Regulatory Elements, Transcriptional

Share to RNA, Neoplasm

Share to Translocation, Genetic

Share to Vidarabine

Source

Identifiers

PMID: 17959858
DOI: 10.1182/blood-2007-07-098681

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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