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Article

p53 pathway gene single nucleotide polymorphisms and chronic lymphocytic leukemia.

Cancer genetics and cytogenetics - 1 Nov 2007

Lahiri Onoshua, Harris Scott, Packham Graham, Howell Melanie

Abstract excerpt

The p53 pathway plays a critical role in chronic lymphocytic leukemia (CLL). The association between the single-nucleotide polymorphism (SNPs) within the p53 gene (R72P) and its downstream target/regulators, BAX (G125A) and MDM2 (SNP309), and clinical parameters/prognostic markers was investigated in 83 CLL patients. Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied,...

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Source

Identifiers

PMID: 17981213
DOI: 10.1016/j.cancergencyto.2007.07.013

Genes

BAX
MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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