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Article

BCL2 gene polymorphism could predict the treatment outcomes in acute myeloid leukemia patients.

Leukemia research - 1 Feb 2010

Moon Joon Ho, Sohn Sang Kyun, Lee Myung-Hoon, Jang Jun Ho, Kim Kihyun, Jung Chul Won, Kim Dong Hwan

Abstract excerpt

The Bcl-2 protein inhibits apoptosis (programmed cell death) of hematopoietic stem cells induced by a variety of noxious stimuli, thus mediating chemoresistance and decreasing chemosensitivity. Higher Bcl-2 expression correlates to an adverse outcome following therapy for acute myeloid leukemia (AML). The current study determined whether a BCL2 gene single nucleotide polymorphism (SNP) could affect treatment...

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Source

Identifiers

PMID: 19520430
DOI: 10.1016/j.leukres.2009.05.009

Genes

BCL2
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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