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Article

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.

Molecular biology of the cell - 1 Jan 2008

Segrelles Carmen, Moral Marta, Lorz Corina, Santos Mirentxu, Lu Jerry, Cascallana José Luis, Lara M Fernanda, Carbajal Steve, Martínez-Cruz Ana Belén, García-Escudero Ramón, Beltran Linda, Segovia José C, Bravo Ana, DiGiovanni John, Paramio Jesús M

Abstract excerpt

Aberrant activation of the Akt pathway has been implicated in several human pathologies including cancer. However, current knowledge on the involvement of Akt signaling in development is limited. Previous data have suggested that Akt-mediated signaling may be an essential mediator of epidermal homeostasis through cell autonomous and noncell autonomous mechanisms. Here we report the developmental consequences of...

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Identifiers

PMID: 17959825
DOI: 10.1091/mbc.e07-08-0764
PMCID: PMC2174171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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