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Article

Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.

Journal of cellular physiology - 1 Nov 2008

Maroulakou Ioanna G, Oemler William, Naber Stephen P, Klebba Ina, Kuperwasser Charlotte, Tsichlis Philip N

Abstract excerpt

The three Akt isoforms differ in their ability to transduce oncogenic signals initiated by the Neu and PyMT oncogenes in mammary epithelia. As a result, ablation of Akt1 inhibits and ablation of Akt2 accelerates mammary tumor development by both oncogenes, while ablation of Akt3 is phenotypically almost neutral. Since the risk of breast cancer development in humans correlates with multiple late pregnancies, we...

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Share to Mice, SCID
Share to Milk
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lactation

Share to Mammary Glands, Animal

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Share to Proto-Oncogene Proteins c-akt

Share to STAT5 Transcription Factor

Source

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Identifiers

PMID: 18561256
DOI: 10.1002/jcp.21518
PMCID: PMC2871282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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