Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis.

Acta pharmacologica Sinica - 1 Nov 2007

Yuan Xiang-wei, Zhu Xiao-feng, Huang Xiu-fang, Sheng Pu-yi, He Ai-shan, Yang Zi-bo, Deng Rong, Feng Gong-kan, Liao Wei-ming

Abstract excerpt

AIM: To determine whether interferon-alpha(IFNalpha) can enhance doxorubicin sensitivity in osteosarcoma cells and its molecular mechanism. METHODS: Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptosis was studied using Flow cytometry analysis, Hoechst33258 staining, DNA fragmentation assay, as well as the activation of caspase-3 and poly (ADP-ribose)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to Genes, p53

Share to In Vitro Techniques

Share to Interferon-alpha

Share to Osteosarcoma

Share to Transcriptional Activation

Source

Identifiers

PMID: 17959036
DOI: 10.1111/j.1745-7254.2007.00662.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis.PMID 17959036Read ↗

Interferonalpha enhances etoposide-induced apoptosis in human osteosarcoma U2OS cells by a p53-dependent pathway.Semantic proximity Read ↗

Silencing Livin gene expression by RNA interference enhanced the chemotherapeutic sensitivity of drug-resistant MG-63 osteosarcoma cells to doxorubicinSemantic proximity Read ↗

Interferon‑α and its effects on cancer cell apoptosis (Review)Semantic proximity Read ↗

Sensitization of interferon-γ induced apoptosis in human osteosarcoma cells by extracellular S100A4Semantic proximity Read ↗

Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.Semantic proximity Read ↗

TNF-α/miR-155 axis induces the transformation of osteosarcoma cancer stem cells independent of TP53INP1Semantic proximity Read ↗

Synergy of interferon-alpha and 5-fluorouracil in human renal cell carcinoma requires p53 activity.Semantic proximity Read ↗

Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53‐dependent pathwaySemantic proximity Read ↗

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathwaySemantic proximity Read ↗

p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines.Semantic proximity Read ↗

Chemotherapy‐induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated <i>via</i> the extrinsic and the intrinsic pathwaySemantic proximity Read ↗

Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.