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Article

Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.

Acta biochimica et biophysica Sinica - 1 Sept 2012

Huang Hongling, Xiao Tian, He Lingfeng, Ji Hongbin, Liu Xin-Yuan

Abstract excerpt

Interferon-β (IFN-β) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN-β (ZD55-IFN-β) exhibits significant anti-tumor activities. However, the underlying mechanisms are not clear. Here we showed that ZD55-IFN-β infection-induced S-phase cell cycle arrest in a p53-dependent manner by...

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Identifiers

PMID: 22842821
DOI: 10.1093/abbs/gms060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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