Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathway

11 Jul 2018

Abstract excerpt

Osteosarcoma becomes the second leading cause of cancer death in the younger population. Current outcomes of chemotherapy on osteosarcoma were unsatisfactory to date, demanding development of effective therapies. Tea is a commonly used beverage beneficial to human health. As a major component of tea, theabrownin has been reported to possess anti-cancer activity. To evaluate its anti-osteosarcoma effect, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29993186
DOI: 10.1111/jcmm.13742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathwayPMID 29993186Read ↗

Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanismsSemantic proximity Read ↗

Theaflavin‐3,3′‐Digallate Plays a ROS‐Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and XenograftsSemantic proximity Read ↗

Huaier Extract Inhibits Proliferation and Promotes Apoptosis via the MAPK Pathway in Human Osteosarcoma CellsSemantic proximity Read ↗

Green Tea-Derived Theabrownin Induces Cellular Senescence and Apoptosis of Hepatocellular Carcinoma via P53 Signaling-Mediated Mechanism Bypassed by JNK RegulationSemantic proximity Read ↗

TP53 in Biology and Treatment of OsteosarcomaSemantic proximity Read ↗

Silencing Livin gene expression by RNA interference enhanced the chemotherapeutic sensitivity of drug-resistant MG-63 osteosarcoma cells to doxorubicinSemantic proximity Read ↗

Reversion of P-glycoprotein-mediated multidrug resistance by diallyl trisulfide in a human osteosarcoma cell lineSemantic proximity Read ↗

Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteinsSemantic proximity Read ↗

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinomaSemantic proximity Read ↗

Silibinin Induces Apoptosis and Suppresses Cell Migration by Targeting the Transforming growth factor-β Signaling Pathway in Osteosarcoma CellsSemantic proximity Read ↗

Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection against osteosarcomaSemantic proximity Read ↗

Investigation of the Effect of Thymoquinone on Egfr/FOXP3 Signaling Pathway in OVCAR3 Human Ovarian Adenocarcinoma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.