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Article

Chemotherapy‐induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated <i>via</i> the extrinsic and the intrinsic pathway

27 Aug 2009

Abstract excerpt

We investigated the downstream mechanisms by which chemotherapeutic drugs elicit apoptosis in hepatocellular carcinoma (HCC). Genomic signatures of HCC cell lines treated with different chemotherapeutic drugs were obtained. Analyses of apoptosis pathways were performed and RNA interference was used to evaluate the role of the p53 family. Endogenous p53, p63 and p73 were upregulated in response to DNA damage by...

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PMID: 19711344
DOI: 10.1002/ijc.24861

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