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Article

Interferonalpha enhances etoposide-induced apoptosis in human osteosarcoma U2OS cells by a p53-dependent pathway.

Life sciences - 13 Feb 2008

Yuan Xiang-Wei, Zhu Xiao-Feng, Liang Sheng-Gen, Fan Quan, Chen Zhong-Xian, Huang Xiu-Fang, Sheng Pu-Yi, He Ai-Shan, Yang Zi-Bo, Deng Rong, Feng Gong-Kan, Liao Wei-Ming

Abstract excerpt

Interferonalpha (IFNalpha) induces cell cycle arrest and triggers apoptosis and chemosensitivity. But the mechanism of IFNalpha in regulating chemosensitivity has not been fully understood. To study whether IFNalpha affected chemosensitivity of osteosarcoma cells, we treated p53-wild U2OS cells and p53-mutant MG63 cells with IFNalpha and etoposide, alone or in combination, and then examined growth inhibition,...

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Identifiers

PMID: 18191951
DOI: 10.1016/j.lfs.2007.11.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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