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Article

Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort.

Virology journal - 25 Oct 2007

Sivakumaran Haran, Wang Bin, Gill M John, Beckholdt Brenda, Saksena Nitin K, Harrich David

Abstract excerpt

Here we investigated the nature and functional consequences of mutations in the HIV-1 tat gene within an epidemiologically-linked AIDS transmission cohort consisting of a non-progressing donor (A) and two normal progressing recipients (B and C). Multiple nonsynonymous mutations in the tat first exon were observed across time in all individuals. Some mutations demonstrated striking host specificity despite the...

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Identifiers

PMID: 17958917
DOI: 10.1186/1743-422X-4-107
PMCID: PMC2174444

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Source receipt: pubmed, retrieved 7 Sept 2026.

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