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Article

Functional Segregation of Overlapping Genes in HIV.

Cell - 15 Dec 2016

Fernandes Jason D, Faust Tyler B, Strauli Nicolas B, Smith Cynthia, Crosby David C, Nakamura Robert L, Hernandez Ryan D, Frankel Alan D

Abstract excerpt

Overlapping genes pose an evolutionary dilemma as one DNA sequence evolves under the selection pressures of multiple proteins. Here, we perform systematic statistical and mutational analyses of the overlapping HIV-1 genes tat and rev and engineer exhaustive libraries of non-overlapped viruses to perform deep mutational scanning of each gene independently. We find a "segregated" organization in which overlapped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27984726
DOI: 10.1016/j.cell.2016.11.031
PMCID: PMC5287106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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