Article
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.
International journal of cancer - 15 Feb 2008
Crosbie Philip A J, McGown Gail, Thorncroft Mary R, O'Donnell Paul N S, Barber Philip V, Lewis Sarah J, Harrison Kathryn L, Agius Raymond M, Santibáñez-Koref Mauro F, Margison Geoffrey P, Povey Andrew C
Abstract excerpt
The association between lung cancer risk and 2 polymorphisms, rs12268840 and rs2308327 (codon K178R), in the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase, which are associated with interindividual differences in activity, have been investigated in 3 hospital-based case-control studies. Genotyping was carried out on 617 subjects of whom 255 had lung cancer. In 2 of the 3 series, there was a...
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