Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer.

doi:10.1158/1055-9965.EPI-04-0612

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Article

Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2005

Zhou Wei, Liu Geoffrey, Park Sohee, Wang Zhaoxi, Wain John C, Lynch Thomas J, Su Li, Christiani David C

Abstract excerpt

Cigarette smoking may induce DNA damage. Lower DNA repair capacities have been associated with higher risk of lung cancer. Excision repair cross-complementing group 1 (ERCC1) is the lead enzyme in the nucleotide excision repair process, and low expression of ERCC1 mRNA levels has been associated with higher risk of cancers. We examined the association between two polymorphisms of ERCC1, 8092C > A (rs3212986) and...

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PMID: 15734977
DOI: 10.1158/1055-9965.EPI-04-0612

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ERCC1

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