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Article

MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies.

PloS one - 1 Jan 2013

Liu Jun, Zhang Renxia, Chen Fei, Yu Cuicui, Sun Yan, Jia Chuanliang, Zhang Lijing, Salahuddin Taufiq, Li Xiaodong, Lang Juntian, Song Xicheng

Abstract excerpt

BACKGROUND: O(6)-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent. METHODS: We carried out a meta-analysis of 44 case-control studies to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24086516
DOI: 10.1371/journal.pone.0075367
PMCID: PMC3784571

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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