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Article

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

7 Nov 2011

Abstract excerpt

Cell cycle-dependent gene expression is often controlled on the transcriptional level. Genes like cyclin B, CDC2 and CDC25C are regulated by cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) promoter elements mainly through repression in G(0)/G(1). It had been suggested that E2F4 binding to CDE sites is central to transcriptional regulation. However, some promoters are only controlled...

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PMID: 22064854
DOI: 10.1093/nar/gkr793

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