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TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis

24 Jun 2016

Abstract excerpt

TAF4b is a gonadal-enriched subunit of the general transcription factor TFIID that is implicated in promoting healthy ovarian aging and female fertility in mice and humans. To further explore the potential mechanism of TAF4b in promoting ovarian follicle development, we analyzed global gene expression at multiple time points in the human fetal ovary. This computational analysis revealed coordinate expression of...

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PMID: 27341508
DOI: 10.1371/journal.pgen.1006128

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