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Article

Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo

9 Nov 2016

Abstract excerpt

E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition to their 'core' cell cycle functions, E-type cyclins also perform unique tissue-specific roles. Here, we applied high-throughput mass spectrometric analyses of mouse organs to define the...

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PMID: 27828963
DOI: 10.1371/journal.pgen.1006429

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