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Article

Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice.

Hormones and behavior - 1 Jan 2008

Gioiosa Laura, Chen Xuqi, Watkins Rebecca, Klanfer Nicole, Bryant Camron D, Evans Christopher J, Arnold Arthur P

Abstract excerpt

We tested the role of sex chromosome complement and gonadal hormones in sex differences in several different paradigms measuring nociception and opioid analgesia using "four core genotypes" C57BL/6J mice. The genotypes include XX and XY gonadal males, and XX and XY gonadal females. Adult mice were gonadectomized and tested 3-4 weeks later, so that differences between sexes (mice with testes vs. ovaries) were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17956759
DOI: 10.1016/j.yhbeh.2007.09.003
PMCID: PMC2713052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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