Article
Genome-wide scan for visceral leishmaniasis susceptibility genes in Brazil.
Genes and immunity - 1 Jan 2007
Jamieson S E, Miller E N, Peacock C S, Fakiola M, Wilson M E, Bales-Holst A, Shaw M-A, Silveira F, Shaw J J, Jeronimo S M, Blackwell J M
Abstract excerpt
A genome-wide scan was conducted for visceral leishmaniasis (VL) in Brazil. Initially, 405 markers were typed in 22 multicase pedigrees (28 nuclear families; 174 individuals; 66 affected). Non-parametric multipoint analysis detected nine chromosomal regions with provisional evidence (logarithm of the odds (LOD) scores 0.95-1.66; 0.003<P<0.018) for linkage. To confirm linkage, 132 individuals (43 affected) from 19...
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