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Article

Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.

PloS one - 1 Jan 2012

Quilez Javier, Martínez Verónica, Woolliams John A, Sanchez Armand, Pong-Wong Ricardo, Kennedy Lorna J, Quinnell Rupert J, Ollier William E R, Roura Xavier, Ferrer Lluís, Altet Laura, Francino Olga

Abstract excerpt

BACKGROUND: The current disease model for leishmaniasis suggests that only a proportion of infected individuals develop clinical disease, while others are asymptomatically infected due to immune control of infection. The factors that determine whether individuals progress to clinical disease following Leishmania infection are unclear, although previous studies suggest a role for host genetics. Our hypothesis was...

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Identifiers

PMID: 22558142
DOI: 10.1371/journal.pone.0035349
PMCID: PMC3338836

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