Article
Genetics and visceral leishmaniasis: of mice and man.
Parasite immunology - 1 May 2009
Blackwell J M, Fakiola M, Ibrahim M E, Jamieson S E, Jeronimo S B, Miller E N, Mishra A, Mohamed H S, Peacock C S, Raju M, Sundar S, Wilson M E
Abstract excerpt
Ninety per cent of the 500,000 annual new cases of visceral leishmaniasis (VL) occur in India/Bangladesh/Nepal, Sudan and Brazil. Importantly, 80-90% of human infections are sub-clinical or asymptomatic, usually associated with strong cell-mediated immunity. Understanding the environmental and genetic risk factors that determine why two people with the same exposure to infection differ in susceptibility could...
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