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Article

The transcriptional cycle of HIV-1 in real-time and live cells.

The Journal of cell biology - 22 Oct 2007

Boireau Stéphanie, Maiuri Paolo, Basyuk Eugenia, de la Mata Manuel, Knezevich Anna, Pradet-Balade Bérangère, Bäcker Volker, Kornblihtt Alberto, Marcello Alessandro, Bertrand Edouard

Abstract excerpt

RNA polymerase II (RNAPII) is a fundamental enzyme, but few studies have analyzed its activity in living cells. Using human immunodeficiency virus (HIV) type 1 reporters, we study real-time messenger RNA (mRNA) biogenesis by photobleaching nascent RNAs and RNAPII at specific transcription sites. Through modeling, the use of mutant polymerases, drugs, and quantitative in situ hybridization, we investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Recovery After Photobleaching

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Source

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Identifiers

PMID: 17954611
DOI: 10.1083/jcb.200706018
PMCID: PMC2064765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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