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Single-Cell and Single-Cycle Analysis of HIV-1 Replication

18 Jun 2015

Abstract excerpt

The dynamics of the late stages of the HIV-1 life cycle are poorly documented. Viral replication dynamics are typically measured in populations of infected cells, but asynchrony that is introduced during the early steps of HIV-1 replication complicates the measurement of the progression of subsequent steps and can mask replication dynamics and their variation in individual infected cells. We established...

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PMID: 26086614
DOI: 10.1371/journal.ppat.1004961

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