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Multiplex single-cell visualization of nucleic acids and protein during HIV infection

27 Nov 2017

Abstract excerpt

Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we develop a microscopy approach, multiplex immunofluorescent cell-based detection of DNA, RNA and Protein (MICDDRP), which is based on branched DNA in situ hybridization technology. MICDDRP enables simultaneous single-cell visualization of HIV (a) spliced...

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PMID: 29192235
DOI: 10.1038/s41467-017-01693-z

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