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Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis

12 Oct 2024

Abstract excerpt

AIMS: In the context of atherosclerosis, macrophages exposed to oxidized low-density lipoproteins (oxLDLs) exhibit cellular abnormalities, specifically in adhesome functions, yet the mechanisms and implications of these adhesive dysfunctions remain largely unexplored. METHODS AND RESULTS: This study reveals a significant depletion of Kindlin3 (K3) or Fermt3, an essential component of the adhesome regulating...

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PMID: 39393814
DOI: 10.1093/cvr/cvae223

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