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Article

Critical role of beta3 integrin in experimental postmenopausal osteoporosis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2005

Zhao Haibo, Kitaura Hideki, Sands Mark S, Ross F Patrick, Teitelbaum Steven L, Novack Deborah Veis

Abstract excerpt

UNLABELLED: We show that mice lacking beta3 integrin are protected from OVX-induced bone loss. Using a lentiviral-based strategy to express beta3 mutants in beta3(-/-) mice, we also show that beta3(S752), but not beta3(Y747/Y759), is important for osteoclastic bone resorption in vivo. INTRODUCTION: Mice lacking the beta3 integrin have dysfunctional osteoclasts and therefore accumulate bone mass with age. Thus,...

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Identifiers

PMID: 16294265
DOI: 10.1359/JBMR.050724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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