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Article

Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2010

Wang Xiaochen, Ward Robert E

Abstract excerpt

During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. A Jun amino-terminal kinase (JNK) cascade in the DME cells induces the expr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20112345
DOI: 10.1002/dvdy.22219
PMCID: PMC2975395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20112345-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.PMID 20112345Read ↗

Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.Semantic proximity Read ↗

Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila.Semantic proximity Read ↗

Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development.Semantic proximity Read ↗

Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure.Semantic proximity Read ↗

The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.Semantic proximity Read ↗

Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.Semantic proximity Read ↗

dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.Semantic proximity Read ↗

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Semantic proximity Read ↗

Modulation of morphogenesis by Egfr during dorsal closure in Drosophila.Semantic proximity Read ↗

Amnioserosa is required for dorsal closure in Drosophila.Semantic proximity Read ↗

The dorsal-open group gene raw is required for restricted DJNK signaling during closure.Semantic proximity Read ↗

Drosophila Dok is required for embryonic dorsal closure.Semantic proximity Read ↗

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