Article
Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2024
Bodmer Nicholas K, Knutsen Russell H, Roth Robyn A, Castile Ryan M, Brodt Michael D, Gierasch Carrie M, Broekelmann Thomas J, Gibson Mark A, Haspel Jeffrey A, Lake Spencer P, Koenitzer Jeffrey R, Brody Steven L, Silva Matthew J, Mecham Robert P, Ornitz David M
Abstract excerpt
BACKGROUND: Latent TGFβ binding protein-2 (LTBP2) is a fibrillin 1 binding component of the microfibril. LTBP2 is the only LTBP protein that does not bind any isoforms of TGFβ, although it may interfere with the function of other LTBPs or interact with other signaling pathways. RESULTS: Here, we investigate mice lacking Ltbp2 (Ltbp2-/- ) and identify multiple phenotypes that impact bodyweight and fat mass, and...
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