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Article

Adverse genetic prognostic profiles define a poor outcome for cystectomy in bladder cancer.

Experimental and molecular pathology - 1 Dec 2007

Gallucci Michele, Vico Erika, Merola Roberta, Leonardo Costantino, Sperduti Isabella, Felici Alessandra, Sentinelli Steno, Cantiani Ruggero, Orlandi Giulia, Cianciulli AnnaMaria

Abstract excerpt

Fluorescence in situ hybridization analysis was performed to evaluate P16 (9p21), P53 (17p13.1), RB1 (13q14), HER2 (17q11.2) genes and chromosomes 3, 7, 9 and 17 in 62 bladder cancer cystectomies. We found chromosome aneusomy ranged between 74.2% and 91.9%. The highest percentage of homozygous deletion was found in the P16 gene (48.4%), while the highest percentage of heterozygous deletion was in the RB1 gene...

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Identifiers

PMID: 17950275
DOI: 10.1016/j.yexmp.2007.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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