Article
Numeric aberration of chromosome 17 is strongly correlated with p53 overexpression, tumor proliferation and histopathology in human bladder cancer.
International journal of urology : official journal of the Japanese Urological Association - 1 Jul 1998
Li B, Kanamaru H, Noriki S, Fukuda M, Okada K
Abstract excerpt
BACKGROUND: This study investigated the relationships between the numeric aberrations of chromosome 17 and p53 expression, the proliferating cell nuclear antigen labeling index (PCNA-LI) and histopathology, to determine their prognostic significance in bladder cancer. METHODS: Using in situ hybridization (ISH) with a biotin-labeled chromosome-specific DNA probe, the copy number of pericentromeric sequences in...
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