Article
Loss of heterozygosity on chromosomes 11 and 17 are markers of recurrence in TCC of the bladder.
British journal of cancer - 14 Dec 2001
Edwards J, Duncan P, Going J J, Grigor K M, Watters A D, Bartlett J M
Abstract excerpt
Approximately 2/3 of patients diagnosed with superficial transitional cell carcinoma of the urinary bladder (TCC) will recur within 2 years. Loss of chromosome 9 and loss of heterozygosity (LOH) at 9q34 in index TCCs identify a subset of patients at high risk of recurrence. This study explores genetic alterations on chromosomes 4, 8, 11 and 17 as predictors of recurrence. A total of 109 carcinomas were...
Topics
- Carcinoma, Transitional Cell
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 4
- Chromosomes, Human, Pair 8
- DNA, Neoplasm
- Disease-Free Survival
- Female
- Genotype
- Humans
- Loss of Heterozygosity
- Male
- Microsatellite Repeats