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Article

Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.

Molecular genetics and metabolism - 1 Feb 2008

Keshavarz Parvaneh, Inoue Hiroshi, Nakamura Naoto, Yoshikawa Toshikazu, Tanahashi Toshihito, Itakura Mitsuo

Abstract excerpt

The LKB1-AMPK-TORC2 signaling pathway controls glucose homeostasis in the liver, and mediates therapeutic effects of insulin-sensitizing antidiabetic agents. To examine whether genetic variations in genes encoding components of this signaling pathway contribute to increased susceptibility to type 2 diabetes, we screened STK11 (LKB1) and CRTC2 (TORC2) genes for genetic variants and conducted a case-control study...

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Source

Identifiers

PMID: 17950019
DOI: 10.1016/j.ymgme.2007.08.125

Genes

CRTC2
PRKAA2
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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