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A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.

Diabetes - 1 Apr 2006

Horikoshi Momoko, Hara Kazuo, Ohashi Jun, Miyake Kazuaki, Tokunaga Katsushi, Ito Chikako, Kasuga Masato, Nagai Ryozo, Kadowaki Takashi

Abstract excerpt

AMP-activated protein kinase (AMPK) acts as a fuel gauge for glucose and lipid metabolism. The gene encoding the alpha2 isoform of the catalytic subunit of AMPK (PRKAA2) is located at one of the Japanese type 2 diabetes loci mapped by our previous genome scan (1p36-32). PRKAA2 is, therefore, a good candidate gene for insulin resistance and type 2 diabetes. We screened all nine exons, their exon-intron boundaries,...

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Identifiers

PMID: 16567511
DOI: 10.2337/diabetes.55.04.06.db05-0727

Genes

PRKAA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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