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Article

Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.

Diabetes - 1 Mar 2006

Sun Maria W, Lee Jennifer Y, de Bakker Paul I W, Burtt Noël P, Almgren Peter, Råstam Lennart, Tuomi Tiinamaija, Gaudet Daniel, Daly Mark J, Hirschhorn Joel N, Altshuler David, Groop Leif, Florez Jose C

Abstract excerpt

AMP-activated protein kinase (AMPK) is a key molecular regulator of cellular metabolism, and its activity is induced by both metformin and thiazolidinedione antidiabetic medications. It has therefore been proposed both as a putative agent in the pathophysiology of type 2 diabetes and as a valid target for therapeutic intervention. Thus, the genes that encode the various AMPK subunits are intriguing candidates for...

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Source

Identifiers

PMID: 16505254
DOI: 10.2337/diabetes.55.03.06.db05-1418

Genes

PRKAA2
PRKAB1
PRKAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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