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Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization

1 Jan 2024

Abstract excerpt

BACKGROUND & AIMS: Sphingosine kinase 1 (SphK1) has distinct roles in the activation of Kupffer cells and hepatic stellate cells in liver fibrosis. Here, we aim to investigate the roles of SphK1 on hepatic macrophage recruitment and polarization in liver fibrosis. METHODS: mice to study the recruitment and polarization of macrophages. The effects of SphK1 originated from macrophages or other liver cell types on...

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PMID: 39305988
DOI: 10.1016/j.jcmgh.2024.101406

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