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Article

Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells.

International immunology - 1 Apr 2007

Jung In Duk, Lee Jun Sik, Kim Yong Joo, Jeong Young-Il, Lee Chang-Min, Baumruker Thomas, Billlich Andreas, Banno Yoshiko, Lee Min Goo, Ahn Soon-Choel, Park Won Sun, Han Jin, Park Yeong-Min

Abstract excerpt

Sphingosine kinase (Sphk) has been shown to be activated by growth factor and survival factors, and one of its products, sphingosine-1-phosphate, plays an important role in the regulation of various cellular responses. However, the effect of Sphk on the maturation and immunostimulatory function of dendritic cells (DCs) still remains largely unknown. In this study, we examined whether sphingosine kinase inhibitor...

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PMID: 17307797
DOI: 10.1093/intimm/dxm006

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SKI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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