Article
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Nature immunology - 1 Jun 2015
Deng Zihou, Ma Shixin, Zhou Hao, Zang Aiping, Fang Yiyuan, Li Tiantian, Shi Huanjing, Liu Mei, Du Min, Taylor Patricia R, Zhu Helen He, Chen Jiangye, Meng Guangxun, Li Fubin, Chen Changbin, Zhang Yan, Jia Xin-Ming, Lin Xin, Zhang Xiaoming, Pearlman Eric, Li Xiaoxia, Feng Gen-Sheng, Xiao Hui
Abstract excerpt
Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired Syk-mediated signaling and abrogated the expression of...
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