Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.

Cell reports - 31 Aug 2021

Ou Peiqi, Stanek Albert, Huan Zack, Roman Christopher A J, Huan Chongmin

Abstract excerpt

B cell tolerance prevents autoimmunity by deleting or deactivating autoreactive B cells that otherwise may cause autoantibody-driven disorders, including systemic lupus erythematosus (lupus). Lupus is characterized by immunoglobulin Gs carrying a double-stranded (ds)-DNA autospecificity derived mainly from somatic hypermutation in the germinal center (GC), pointing to a checkpoint breach of GC B cell tolerance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Enzyme Activators
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred NZB

Share to Protein Kinase C-delta

Share to Transferases (Other Substituted Phosphate Groups)

Source

Identifiers

PMID: 34469734
DOI: 10.1016/j.celrep.2021.109624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.PMID 34469734Read ↗

PKCδ Protects Against Lupus AutoimmunitySemantic proximity Read ↗

Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.Semantic proximity Read ↗

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce ToleranceSemantic proximity Read ↗

Protein Kinase C δ: a Gatekeeper of Immune Homeostasis.Semantic proximity Read ↗

Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.Semantic proximity Read ↗

Defects in Germinal Center Selection in SLESemantic proximity Read ↗

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus.Semantic proximity Read ↗

T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice.Semantic proximity Read ↗

A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal centers.Semantic proximity Read ↗

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.Semantic proximity Read ↗

B Cell–Intrinsic CD84 and Ly108 Maintain Germinal Center B Cell ToleranceSemantic proximity Read ↗

Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.