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Transcriptional properties of feline p53 and its tumour-associated mutants: a yeast-based approach.

Mutagenesis - 1 Nov 2007

Cardellino Umberto, Ciribilli Yari, Andreotti Virginia, Modesto Paola, Menichini Paola, Fronza Gilberto, Pellegrino Claudio, Inga Alberto

Abstract excerpt

Mutations at the tumour suppressor gene TP53 are associated with nearly half of human cancers, but they appear to be rare ( approximately 10%) in feline neoplasms. The reasons for this difference are presently unclear but might be related to evolutionary divergence of p53 functions. To begin exploring this issue, we developed a yeast-based functional assay to measure the transcriptional ability of wild-type (wt)...

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PMID: 17947339
DOI: 10.1093/mutage/gem038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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