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Article

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication.

The Journal of biological chemistry - 23 Jan 2015

Tay Moon Y F, Saw Wuan Geok, Zhao Yongqian, Chan Kitti W K, Singh Daljit, Chong Yuwen, Forwood Jade K, Ooi Eng Eong, Grüber Gerhard, Lescar Julien, Luo Dahai, Vasudevan Subhash G

Abstract excerpt

Dengue virus multifunctional proteins NS3 protease/helicase and NS5 methyltransferase/RNA-dependent RNA polymerase form part of the viral replication complex and are involved in viral RNA genome synthesis, methylation of the 5'-cap of viral genome, and polyprotein processing among other activities. Previous studies have shown that NS5 residue Lys-330 is required for interaction between NS3 and NS5. Here, we show...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25488659
DOI: 10.1074/jbc.M114.607341
PMCID: PMC4303688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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