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Article

Crystal structure of Middle East respiratory syndrome coronavirus helicase

26 Jun 2017

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidoviruses, thus making it an important target for drug development. We report here the first structure of full-length coronavirus helicase, MERS-CoV nsp13. MERS-CoV...

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PMID: 28651017
DOI: 10.1371/journal.ppat.1006474

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