Article
Molecular models of NS3 protease variants of the Hepatitis C virus.
BMC structural biology - 21 Jan 2005
da Silveira Nelson J F, Arcuri Helen A, Bonalumi Carlos E, de Souza Fátima P, Mello Isabel M V G C, Rahal Paula, Pinho João R R, de Azevedo Walter F
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) currently infects approximately three percent of the world population. In view of the lack of vaccines against HCV, there is an urgent need for an efficient treatment of the disease by an effective antiviral drug. Rational drug design has not been the primary way for discovering major therapeutics. Nevertheless, there are reports of success in the development of inhibitor using...
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