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Article

Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA

7 Aug 2006

Abstract excerpt

Dengue virus, a member of the family Flaviviridae of positive-strand RNA viruses, has seven non-structural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5. Except for enzymic activities contained within NS3 and NS5, the roles of the other proteins in virus replication and pathogenesis are not well defined. In this study, a physical interaction between NS4B and the helicase domain of NS3 was identified by using...

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Identifiers

PMID: 16894199
DOI: 10.1099/vir.0.81844-0

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