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Article

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.

The Journal of biological chemistry - 11 Jun 2010

Luo Dahai, Wei Na, Doan Danny N, Paradkar Prasad N, Chong Yuwen, Davidson Andrew D, Kotaka Masayo, Lescar Julien, Vasudevan Subhash G

Abstract excerpt

The dengue virus (DENV) NS3 protein is essential for viral polyprotein processing and RNA replication. It contains an N-terminal serine protease region (residues 1-168) joined to an RNA helicase (residues 180-618) by an 11-amino acid linker (169-179). The structure at 3.15 A of the soluble NS3 protein from DENV4 covalently attached to 18 residues of the NS2B cofactor region (NS2B(18)NS3) revealed an elongated...

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Identifiers

PMID: 20375022
DOI: 10.1074/jbc.M109.090936
PMCID: PMC2881804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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