Article
Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis.
Journal of neuroimmunology - 1 Sept 2007
Zivković Maja, Djurić Tamara, Dincić Evica, Raicević Ranko, Alavantić Dragan, Stanković Aleksandra
Abstract excerpt
Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p = 0.01), was found in female MS patients. In addition,...
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