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Article

Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease.

Journal of neuroimmunology - 29 Sept 2009

Fernandes Karla S S, Brum Doralina Guimaraes, Sandrim Valeria Cristina, Guerreiro Carlos Tostes, Barreira Amilton Antunes, Tanus-Santos José Eduardo

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease causing severe neurological disability. This study was carried out in order to determine whether the MMP-9 C(-1562)T and (CA)(13-25) polymorphisms are associated with MS. A total of 165 patients (92 whites/73 mulattos) and 191 controls (96 whites/95 mulattos) were enrolled in the study. While no difference in C(-1562)T polymorphism was observed between MS and...

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PMID: 19631393
DOI: 10.1016/j.jneuroim.2009.07.004

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