Article
Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy.
Blood - 14 Aug 2014
Simonetti Giorgia, Bertilaccio Maria Teresa Sabrina, Ghia Paolo, Klein Ulf
Abstract excerpt
Mouse models that recapitulate human malignancy are valuable tools for the elucidation of the underlying pathogenetic mechanisms and for preclinical studies. Several genetically engineered mouse models have been generated, either mimicking genetic aberrations or deregulated gene expression in chronic lymphocytic leukemia (CLL). The usefulness of such models in the study of the human disease may potentially be...
Topics
- Animals
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- Chromosomes, Mammalian
- Disease Models, Animal
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Mice, Inbred NZB
- Mice, Knockout
- Mice, Transgenic
- Models, Genetic
- Phenotype
- Signal Transduction
- Tumor Microenvironment