Article
Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.
Chemical research in toxicology - 1 Nov 2007
Delaney Sarah, Delaney James C, Essigmann John M
Abstract excerpt
DNA-damaging agents usually produce a vast collection of lesions within the genome. Analysis of these lesions from the structural and biological viewpoints is often complicated by the reality that some of the lesions are chemically fragile, leading to an even larger set of secondary and tertiary products. In an effort to deconvolute complex DNA-damage spectra, a strategy is presented whereby an oligonucleotide...
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