Article
EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women.
Breast cancer research and treatment - 1 Sept 2008
Wang Yan, Tian Tian, Hu Zhibin, Tang Jinhai, Wang Shui, Wang Xuechen, Qin Jianwei, Huo Xiang, Gao Jun, Ke Qiao, Jin Guangfu, Ma Hongxia, Wang Xinru, Shen Hongbing
Abstract excerpt
Epidermal growth factor (EGF), a potent mitogenic peptide, plays an important role in the development of cancers, including breast cancer. Previous studies showed that plasma EGF levels may influence the risk of cancer. In the current study, we hypothesized that genetic variants in the promoter region of EGF may influence plasma EGF levels and therefore are associated with breast cancer susceptibility. We...
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